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KMID : 1140120070120020092
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Cancer Prevention Research
2007 Volume.12 No. 2 p.92 ~ p.97
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Membrane Type-Matrix Metalloproteinase-1 Increase the Invasive and the Angiogenic Activities of Human Endothelial Cells
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Jeong Joo-Won
Park Chan
Huh Young-Buhm
Kim Jung-Hye
Ahn Hee-Kyung
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Abstract
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Matrix metalloproteinases (MMPs) have been reported to play critical roles in the cell migration and matrix remodeling during invasion and metastasis. Among these MMPs, membrane-type MMP-1 (MT1-MMP) is an important molecule that can trigger the invasion of tumour cells by activating MMP-2 on the tumour cell surfaces. In this study, to investigate the roles of the MT1-MMP by the matrix remodeling of endothelial cells, MT1-MMP expression vector was transfected into human umbilical vein endothelial cells (HUVECs). Increased expression of MT1-MMP in HUVECs enhanced the activation of MMP-2 and invasion of endothelial cells. Moreover, the capacity of tube formation was increased by MT1-MMP overexpression. These observations indicate that MT1-MMP is involved in the angiogenic process of endothelial cells in vitro. (Cancer Prev Res 12, 92-97, 2007)
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KEYWORD
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MT1-MMP, Invasion, Angiogenesis, HUVEC
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